What does a Botox injection feel like? January 19, 2023 Botox is an in-office procedure that typically takes about 45 minutes to complete. Before your Botox treatment begins, Dr. Downey or Dr. Bullocks will apply a topical anesthetic to your treatment areas. This is to ensure you are as comfortable and pain-free as possible throughout the entirety of your treatment. Dr. Downey or Dr. Bullocks will then make a series of strategically placed Botox injections into your desired treated areas, typically around the forehead, eyes, brow, and the bridge of the nose. Because Botox is a minimally invasive treatment, there is no downtime or recovery period associated with treatment.